Approximately eight percent of patients who have a stroke will experience (CPPS), a major cause of central neuropathic pain. After a cortical, subcortical, thalamic, or lateral brainstem stroke, a lesion in the spinothalamiocortical pathway may develop, leading to CPPS. There are several pain conditions that may present after stroke, such as gout, deep vein thrombosis, and musculoskeletal pain - CPPS is a diagnosis of exclusion.
There are five medication classes useful in treating CPSP:
There are five medication classes useful in treating CPSP:
- Membrane stabilizers: carbamazepine, lidocaine, mexiletine
- Aminergic agents: amitriptyline, duloxetine
- Glutamate antagonists: ketamine, lamotrigine
- GABA agonists: thiopental, propofol, baclofen
- Calcium channel blockers: gabapentin, pregabalin